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The result is denatured protein that dissolves in the water and looks perfectly fine but has reduced or zero biological activity
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Perillo B, Di Donato M, Pezone A, Di Zazzo E, Giovannelli P, Galasso G, Castoria G, Migliaccio A (2020) ROS in cancer therapy: the bright side of the moon
NO also avidly binds to the heme moiety of hemoglobin (in red blood cells) and the heme moiety of the enzyme guanylyl cyclase , which is found in vascular smooth muscle cells and most other cells of the body
For peripheral vascular disease, where reduced blood flow to the extremities causes pain and tissue damage, this collateral activation mechanism could theoretically provide meaningful benefit