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Clinical studies show that patients may lose approximately 10% to 20% of body weight over time when these medications are combined with appropriate lifestyle changes

Because biological pathways take time to adjust, results develop progressively rather than instantly

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These receptors also influence circadian signaling pathways, meaning the medication can indirectly affect sleep onset, continuity, and REM cycles in some individuals

Barrington P, Chien JY, Showalter HD et al (2011) A 5-week study of the pharmacokinetics and pharmacodynamics of LY2189265, a novel, long-acting glucagon-like peptide-1 analogue, in patients with type 2 diabetes