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The REMODEL trial investigates the kidney effects of subcutaneous semaglutide versus placebo in people with T2D (52)

When Pinto has a patient who asks about weaning off their GLP-1 or spacing out dosing, he is very receptive to the conversation

doi: 10.1007/s00125-015-3660-2 16 WolvertonDBlairMM

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However, GLP-1R expression and action extend beyond these regions to include the brainstem, hypothalamic nuclei, and the amygdala (Larsen et al., 1997

This corresponds to the lower therapeutic dose from GLORY-2