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Side effects Semaglutide may also cause various side effects, the frequency of which is shown in the Fig

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Expect checks for thyroid function, kidney and liver panels, fasting glucose or HbA1c if you have metabolic risk, and a review of any personal or family history of thyroid cancer or MEN2 because semaglutide has specific safety considerations in that area

Yes, headaches are a recognized side effect of semaglutide medications including Ozempic, Wegovy, and Rybelsus

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So we do have weight loss medications that we've used for a long time, and they are safe and effective