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Notably, chemical chaperones (4-PBA, TUDCA) enhance Gq signaling without reversing this switch, while ER stress-associated UPR factors XBP1 and ATF6 selectively amplify Gs signaling

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Under physiological conditions, ROS act as signaling molecules that regulate differentiation, proliferation, apoptosis, and the immune response

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However, the risk of developing skin cancer outweighs the potential benefits of sun exposure

Biochemical assays revealed higher intracellular TG in the model groups compared with control groups, while PGPIPN treatment could decrease TG levels (Figure 2B)