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Microbiome depletion : Antibiotics, poor diet or stress can wipe out beneficial gut flora, which are protective against dysbiosis and overgrowth, and support normal gut functioning

An alternative question, and perhaps not mutually exclusive, is when should globus pallidus stimulation not be the primary choice

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Cardiovascular genetics: the role of genetic testing in diagnosis and management of patients with hypertrophic cardiomyopathy