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Key Advances in AMY3R/CTR-Targeted Drug Discovery To facilitate drug discovery targeting amylin/calcitonin receptors, the ICE team evaluated non-lipidated peptide hCT and human amylin and the lipidated peptide cagrilintide using the HTRF-cAMP assay across multiple host cell lines

In addition, co-culture experiments with cancer-associated fibroblasts (CAFs) and T cells revealed that CAFs could induce drug resistance, while microsatellite instability-high (MSI-H) tumors showed strong T cell-mediated cytotoxicity [33]

doi: 10.1016/j.bbamcr.2006.08.039 44 TurrensJFBoverisA

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Only a smaller number of cells develop under standard culture conditions when either vitamin B2, B6, or B9 is present