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These may have more adverse side effects and additional risks

however, in the metabolic context created by concurrent GLP-1 and GIP activation (which provides the insulin response to counterbalance glucose effects), glucagon receptor activation primarily drives hepatic fat oxidation, increases resting energy expenditure, and promotes lipolysis from adipose tissue

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Collectively, these two studies elucidate the role of EAT in AF from two distinct dimensions: EAT heterogeneity (pathological complexity) and overall mass (early quantitative changes)

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MASLD has become one of the most common chronic liver diseases worldwide, affecting more than 30% of the global population