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While agonist peptides based on either scaffold are potent in rat obesity models 2,10,11,12,13 , only a transient weight loss effect is observed with sCT in mouse diet-induced obesity (DIO) models 14 , indicating that there may be distinctions in the mode of action of individual dual agonists

At the molecular level, chronic AOD9604 administration upregulates 3 adrenergic receptors in fat tissue, reversing obesityrelated suppression of these fatburning receptors [9]

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GLP-1 provides powerful appetite suppression through brain receptors

While the original protein exists in the stomach, the 15-amino acid fragment that comprises BPC 157 does not occur naturally