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Keywords: adipose tissue remodeling, beige adipocytes, extracellular matrix remodeling, GLP-1 receptor agonist, immunometabolism, mitochondrial biogenesis, semaglutide, type 2 diabetes mellitus, visceral adiposity 1

This medication works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to meals, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

However, levels reduce due to stress, aging, and environmental exposure

Opa1 also participates in cristae formation [312]

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Using frequent sampling of urine and saliva in multiple well-trained bonobos we aim to (1) describe the decreasing urinary and salivary cortisol pattern during a day without a stress response challenge to serve as a base-line (control)