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There is another mechanism showing that GLP-1RA treatment regulates Ca 2+ levels due to reductions in the ryanodine receptor (RyR)2 phosphorylation and suppression of the activation of calmodulin-dependent protein kinase (CaMK)-II [77]

When this effect is no longer present, the body gradually shifts back towards its previous physiological state

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As for the DUAL-1 study, the primary endpoint was to prove non-inferiority of the combination compared to glargine and superiority compared to lixisenatide