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IGF-1 can also regulate GPER expression in ER+ breast cancer cells through the IGF-IR/ERK/c-fos/AP1 transduction pathway ( Clinical Trials Targeting IGF Overview in Endocrine-Related Cancers As IGF-1R has been implicated in several cancer types it has garnered a great deal of interest as a therapeutic target

Given Retatrutides longer half-life compared to earlier GLP-1 medications, some practitioners recommend 3 months for additional safety margin

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