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Moreover, NAD + acts as a substrate of sirtuins, PARPs, and cADPRSs in many different signaling pathways, including DNA repair, posttranslational modifications, inflammatory responses, senescence, and apoptosis

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doi:10.15585/mmwr.ss7007a1

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However, gastrointestinal side effects remain very common, with nausea affecting approximately 40-45% of users and overall gastrointestinal adverse events occurring in the majority of patients in clinical trials