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111 A remaining question is whether potential controlling factors including allosteric control of glycogen synthase (GS) and phosphorylases via glucose-6-phosphate (G6P), 112 in addition to the insulin-independent transport of glucose across the hepatocellular plasma membrane by GLUT2 (as a glucose-sensitive protein in liver cells), can impact hepatic glycogen metabolism

J Endocr Soc 2023;7:bvad056

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Kumbhani DJ, Cannon CP, Beavers CJ, et al

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The SELECT trial showed Wegovy reduced MACE by 20% (HR 0.80) in adults with established cardiovascular disease and obesity or overweight without diabetes