This gives Mounjaro a slight advantage in achieving faster weight-loss results. In a head-to-head clinical trial, Lilly reported that tirzepatide led to an average weight reduction of 20.2%, compared to 13.7% with semaglutide after 72 weeks of treatmenta 47% greater relative weight loss with tirzepatide
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This is a theoretical risk, not a demonstrated one, and it should factor into who avoids this stack (see below)
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The answer is largely financial
Furthermore, recent studies have investigated the neuroprotective effect of lactate against oxidative stress, showing that lactate triggers antioxidant defenses and pro-survival pathways, through the production of NADH, reduction of intracellular pH and a mild Reactive Oxygen Species (ROS) burst 30,31,32
