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Cold constricts blood vessels and reduces histamine release, which can ease itching

Am J Heart 229:6169 Kadawaki T, Isendahl JK, Khalid U, Lee SW et al (2022) Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

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Although setmelanotide effectively treats these forms of genetic obesity, the compound had mixed results during nonclinical and clinical evaluation for general obesity

Castillo-Hernandez KG, Espinosa A, Molina-Segui F, AyusoPeraza G, Mena-Macossay L, Mendez-Dominguez N, et al