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6 Adverse effects of GLP1-RA In contrast to the advantages of GLP-1RA the analogues have gastrointestinal side effects distinctly nausea, emesis and reduced appetite with lower risk of hypoglycemia compared to other glucose lowering drugs (110)

Previous allodynia history People who have experienced allodynia from other causes, such as migraines, fibromyalgia , complex regional pain syndrome, or shingles, may have a lower threshold for developing medication-associated allodynia

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McGuire, found that oral semaglutide reduced major adverse cardiovascular events (MACE) to 3.1 events per 100 person-years, compared to 3.7 events in the placebo group a 14% reduction (HR 0.86) over a median follow-up of 49.5 months

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