This phenomenon, sometimes called tolerance or tachyphylaxis, is not well-studied specifically for semaglutide, but it is reported frequently in practice
The medication builds up in your system over four to five weeks of consistent dosing until it reaches what pharmacologists call "steady state," a stable concentration that remains relatively constant between doses
Importantly, the SmPC states that Ozempic is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis
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Keep a realistic timeline for results in mind and prioritize stable blood sugar over rapid weight loss during transitions
And GLP-1s may hold even more promise for other chronic illnesses