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Intracellularly, GSH is maintained in its thiol-reduced form by NADPH-dependent enzymes (glutathione disulfide bond (GSSG) reductase)

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In contrast, more severe toxicity was observed when rat or human liver slices were incubated with AMAP than when mouse liver slices were incubated with the compound, or when rat and human liver slices were incubated with acetaminophen

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