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When to Seek Medical Advice About Feeling Cold Seek medical advice if cold sensations are persistent or accompanied by fatigue, pallor, hair loss, or discoloured fingers and toes, as these may indicate anaemia, thyroid dysfunction, or Raynaud's phenomenon

Deficiency can show up as fatigue, weakness, numbness/tingling, balance problems, memory issues, and megaloblastic anemia

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Oxidative stress results from an imbalance between antioxidants and oxidants (i.e., radicals)

Meanwhile, emerging evidence highlights BBRs novel molecular targets for anti-obesity: (1) AMPK/PGC-1 axis activation and SIRT1-mediated deacetylation