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Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway

doi: 10.1038/s41420-024-02078-0 8 KistMVucicD

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10.3748/wjg.v10.i8.1125 73 YinZ.WangQ.ChengH

Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25