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Safety was monitored throughout
Ethical approval All procedures, protocols, and animal handling have been reviewed and approved by the Mansoura University Committee
1 The study details 800 participants in the interim analysis (1,197 total enrolled) with biopsy-confirmed MASH and moderate to severe fibrosis (stage F2 or F3) Participants were randomly assigned to receive semaglutide 2.4 mg weekly or placebo Treatment lasted 72 weeks 2:1 randomisation (534 semaglutide, 266 placebo) Resolution of MASH (primary outcome) Fibrosis improvement (primary outcome) Combined outcomes About a third (32.7%) of participants taking semaglutide achieved both MASH resolution and fibrosis improvement, compared to 16.1% on placebo
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Small, science-backed shifts today can compound into meaningful, sustainable progress over time
Next Steps for Patients If youre currently using compounded semaglutide or tirzepatide, its crucial to: Schedule a Consultation : Meet with your healthcare provider to discuss transitioning to FDA-approved medications
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