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Additionally, heterogeneous astrocytes distributed throughout the brain exacerbate disease progression and compromise the BBB by releasing inflammatory factors and chemokines [55, 56]

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Research demonstrates that TB-500 induces hair growth through enhanced stem cell migration and differentiation, with studies showing TB-500-overexpressing mice achieve complete hair regrowth in 11 days compared to 13 days for wild-type controls and 16 days for TB-500 knockout animals, indicating dose-dependent effects on follicle cycling kinetics