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J Clin Endocrinol Metab 108 ,1676-1685 (2023)
Formal micronutrient monitoring guidelines specific to GLP-1 weight loss remain underdeveloped
Our patch-clamp electrophysiology results corroborate these findings, demonstrating that GLP-1RAs directly activate DMH GLP-1R neurons, which in turn send inhibitory projections to ARC AgRP/NPY neurons [69]
Therefore, GLP-1R is considered a potential therapeutic target for diseases related to brain glucose metabolic disorders
Over the last several years, GLP-1 prescriptions have surged because these drugs are widely discussed not only for diabetes control but also for weight loss and long-term chronic weight management, including use patterns that expanded public awareness and demand
Mild elevations in pancreatic enzymes (lipase, amylase) can occur with tirzepatide use without clinical pancreatitis and should be interpreted in the appropriate clinical context
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