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Lysosomal cysteine cathepsins B and L are often overexpressed in aggressive tumors, and upon their transfer to the invadosomes and following secretion to the extracellular space, they can participate in the degradation of the extracellular matrix [46, 48]

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10.1016/j.jep.2017.09.021 6 CaiH.WangJ.LuoY.WangF.HeG.ZhouG.et al (2021)

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LDM_res demonstrates superior performance, minimizing errors to nearly zero over most of the domain, with a uniform distribution over land and sea