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When paired with nutrition and lifestyle support, GLP-1 medications can be a powerful weight loss tool

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Before anyone considers GLP-1 therapy at any dose let me be clear about who needs to avoid these medications: Personal or family history of medullary thyroid cancer or MEN-2 syndrome contraindicated History of pancreatitis may not be safe Severe gastroparesis these drugs will worsen it Pregnancy or active conception planning not recommended These are real medications with real side effects: nausea, vomiting, constipation, gallbladder problems

Functional enrichment analysis was performed with DAVID using the pathways related to metabolism from the KEGG database annotation

10.1016/j.freeradbiomed.2014.02.019 240 MitchellJ.PaulP.ChenH

Why it matters: The program is designed for people with a BMI of 21 or higher, including many in the healthy weight range, as defined by the CDC (BMI of 18.5 to 24.9)