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Cell (2022) 185(20):365270
doi:10.1080/13813455.2016.1273365 Aydin AF, Kondakci G, Hatipoglu S, Dogru-Abbasoglu S, Uysal M
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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene targeted by every GLP-1 compound), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (a transcription factor tied to glucose homeostasis and GLP-1 secretion) map the metabolic terrain a compound works through
These results were validated in the Food and Drug Administration Adverse Event Reporting System database (OR 0.72
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