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[2] While metformin has shown modest benefit in preventing progression to diabetes in the Diabetes Prevention Program, using tirzepatide specifically to treat prediabetes would be considered off-label and requires careful clinical judgment and shared decision-making

de Vries LH, Lodewijk L, Willems SM, Dreijerink KMA, de Keizer B, van Diest PJ, Schepers A, Bonenkamp HJ, van Engen-van Grunsven I, Kruijff S et al : SSTR2A expression in medullary thyroid carcinoma is correlated with longer survival

Step up to 0.5mg, then 1mg, then 2mg every 4 weeks as tolerated

Diabetes Care, 43 ,

Keep it away from eyes and lips and mucosal membranes

What we know from the research is that most patients who stop taking a GLP-1 regain weight and lose the cardiometabolic health benefits