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The investigators interpreted the effects as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in genetic models

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Investigators reported a 38% higher risk of kidney cancer in GLP-1 users compared to non-users, noting that while the result was marginally nonsignificant, it remains concerning due to the widespread use of these drugs

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Overweight adults with comorbidities : This means your BMI is 27 or above and you have at least one weight-related health condition, such as high blood pressure or type 2 diabetes