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Am J Respir Crit Care Med 168:516521

8 (2), e1002521

239 Elevated expression of ATG genes, including ATG4B, ATG4D, ATG5, and BECN1, underscores its mechanistic relevance, 240 and ATG4B knockdown sensitizes cells to therapy

It scavenges free radicals and reduces oxidative stress

Pre-metastatic niches: organ-specific homes for metastases

The implication of mitochondria in AS pathophysiology is not entirely surprising since mitochondria serve as the hub of multiple critical cellular processes that affect cell viability and functionality beyond ATP production, such as calcium signaling, apoptosis, and neuronal excitability [14,15,16,17,18,19]