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The argument goes like this

Does the combination affect fertility or pregnancy

Mounjaro slows the rate at which food leaves the stomach, which can influence digestion, but it does not directly change bile production

Animal studies reinforce compartment-specific skeletal changes with CR

Tirzepatide is a dual GIP/GLP-1 receptor agonist that slows gastric emptying and reduces appetite, which may affect protein tolerance

Filip Krag Knop has served on scientific advisory panels and/or been part of speakers bureaus for, served as a consultant to, and/or received research support from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Carmot Therapeutics, Eli Lilly, Gubra, MedImmune, MSD/Merck, Mundipharma, Norgine, Novo Nordisk, Sanofi, and Zealand Pharma