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Pep-21 treatment specifically silenced target miR-21 in B16 melanoma cells and M2 macrophages, reducing tumor cell migration and inhibiting tumor progression

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In this review, we present the senolytic drugs as a promising way to treat age-related diseases but also their limitations during clinical development

After 8 weeks of treatment, the weight decreased by -1.4-3.3kg (122)

Before they were decapitated, 300 mL physiological saline was administered to perform cardiac perfusion