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They also inhibit glucagon release from the alpha cells of the islets of Langerhans

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There could be several reasons

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When patients lose weight through any methodwhether medication, diet, or surgerythe loss typically includes both fat mass and lean body mass (which includes muscle, bone, and water)

Konopka et al., 2020), cytoplasmic mislocalization of nuclear proteins (Neumann et al., 2006), mitochondrial dysfunction (Albers and Beal, 2000), glutamate excitotoxicity (Shaw and Ince, 1997), proteasomal and autophagic dysfunction (Chen et al., 2012), ER stress (Nagata et al., 2007