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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

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This is based on the selectivity and high affinity of Ni-NTA(nickel nitriloacetic acid) reins for proteins containing his tag

pylori biotin protein ligase (HpBPL)-mediated catabolism and -glutamyl transpeptidase-induced glutathione hydrolysis, depleting antioxidants while inducing dendritic cell tolerance

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In particular, rapid trimethylation of histone H3 at lysine 4 (H3K4me3) was observed in mouse livers after weekly 6-hour light-dark phase advances 223