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doi: 10.1186/s12885-018-4824-5 70

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Design and synthesis of novel imidazo [4, 5-b] pyridine based compounds as potent anticancer agents with CDK9 inhibitory activity

The compound when taken orally as a sweetener caused liver failure

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When CJC-1295 left out fridge in reconstituted form, two degradation pathways accelerate simultaneously: oxidative modification of methionine residues at positions critical for receptor binding, and hydrolytic cleavage of peptide bonds catalyzed by trace water and ambient heat