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This results in: Increased satiety signaling in the brain Slowed gastric emptying Improved insulin sensitivity and post-meal blood sugar regulation Weight loss with semaglutide is driven primarily by appetite regulation and metabolic effects mediated through GLP-1 pathways. Tirzepatide: Dual GIP and GLP-1 Agonist Tirzepatide, the medication in Zepbound, activates two incretin receptors : GLP-1 GIP (glucose-dependent insulinotropic polypeptide) GIP appears to further enhance insulin sensitivity and may amplify appetite regulation when combined with GLP-1

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Current evidence indicates no increased risk of thyroid cancer , though potential risks should be discussed with healthcare providers to effectively manage this side effect

Any recently developed oral melanotic maculae that are irregularly pigmented or have recently increased in size should be viewed with suspicion and microscopically examined to exclude melanoma

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