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Hydroxocobalamin in Neo-B12 Injection is the precursor for the enzyme co-enzyme B12 and this reacts with the enzyme Methylmalonyl Coenzyme A mutase, an isomerase required for the conversion of methylmalonate to succinate, an important step in production of lipoprotein in myelin sheath tissue, which could cause neurological problems

Arg Substitution: Lysine at position 34 is replaced by Arginine

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This means liraglutide reaches steady-state concentrations within 3 to 5 days, whereas semaglutide requires 4 to 5 weeks

doi: 10.1093/toxsci/kfh286

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