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Holst's scientific work has focused on the regulatory peptides of the pancreas and the gut and their importance in the regulation of the functions of the GI-tract and metabolism, with particular focus on blood glucose and appetite regulation, obesity and diabetes

Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk

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or Diagnosis of morbid obesity with a BMI of 35 or more, along with one or more weight-related medical conditions such as cardiovascular disease, hypertension (high blood pressure), high cholesterol, Type 2 diabetes, or sleep apnea There are also criteria to approve continuation of treatment in adults, such as losing and maintaining at least four percent from the baseline weight after 16 weeks at a maintenance dose