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Human evidence - Phase 2 NEJM (Jastreboff et al., 2023) 338 adults with obesity but no diabetes

10.1007/978-3-319-72041-8_11 6 AimonenK.ImaniM.HartikainenM.SuhonenS.VanhalaE.MorenoC.et al (2022)

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In an unmatched population-based casecontrol approach, we estimated a sample size of 258 individuals with QUANTO software, version 1.2.4, assuming a log-additive inheritance model at 5% significance and 80% power and using the following parameters based on our previous study 20 : an environmental exposure to Hg of 2.5%, a population risk of reduced estimated glomerular filtration rate (eGFR

The peptide preserves mitochondrial integrity by protecting against superoxide radical accumulation in mitochondrial compartments, maintaining efficient energy production and preventing mitochondrial-derived oxidative stress