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Clinical trials demonstrated average weight reductions of 15-21% of body weight over 72 weeks in people with obesity (SURMOUNT-1), while more modest weight loss was observed in type 2 diabetes patients (SURPASS trials)

However, a recently published case report showed that the condition of a 59-year-old woman who was previously confirmed to have MC by colonoscopy and biopsy was resolved after the patient began intravenous immunoglobulin administration despite continuing to take anthraquinone laxatives.43 However, the specific mechanism and long-term clinical effects are still unclear, and this approach may be a new method to treat MC in the future

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Regular moderate or intense exercise prevents Depression-Like behavior without change of hippocampal Tryptophan content in chronically Tryptophan-Deficient and stressed mice