glp-1 long term studies GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction Researchers at UC Irvine issue

The first agent in this class was approved in 2005 for type 2 diabetes, and ongoing studies continue to look at their broader applications, long-term benefits and safety profile

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(2017) Associations of Weight Gain From Early to Middle Adulthood With Major Health Outcomes Later in Life Rubino, Francesco, et al

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In T2DM patients, lixisenatide reduced activation in brain areas including the hypothalamus, temporal lobar regions, lateral ventricle, and cortical areas in obese individuals in contrast to lean T2DM individuals, who showed increased activation in the areas [38]

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