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Many people who think they react to gluten actually experience the nocebo effect

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Loniewska MM et al

Mechanistic studies suggest that food-induced pain in IBS-C may involve dietary antigen-specific IgE-mediated immune responses, triggering mast cell activation and the release of tryptase, histamine, and prostaglandin E2 via TLR4 signaling [39, 40]

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When Tri-Immune May Be Worth Discussing The best candidate is not simply someone who wants more immunity, but someone whose goals, health history, and nutrient status make a concentrated IM blend reasonable