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The cellular anti-inflammatory action of the nanosheets is achieved by scavenging intracellular ROS of M1 macrophages and promoting their transition to M2 phenotype, which largely prevents mBMSC apoptosis, while the Zn 2+ released from the degrading nanosheets upregulates the ALP level of mBMSCs, facilitating osteogenic differentiation and biomineralization

However, studies have yielded inconsistent results [115, 116]

It hosts an exceptionally dense microbial population (10 11 cells/mL), dominated by bacteria but also including archaea, protozoa, and anaerobic fungi, a composition distinct from monogastric systems (Table 1)

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The cost to Medicare will depend on how many enrollees actually participate