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If nausea persists beyond 8 weeks at a stable dose, or if it's severe enough to cause vomiting more than twice weekly, the prescriber should consider slowing dose escalation further or temporarily reducing to the prior tolerated dose

No therapeutic or clinical outcome is represented

Journal of the International Society of Sports Nutrition , 14 , 20

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That said, these trials used different populations and durations, so direct comparison has limits

Retatrutide is currently in Phase 3 clinical trials, which means it successfully passed Phase 1 (safety in healthy volunteers) and Phase 2 (efficacy and safety in target population)