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Acknowledgements We are grateful to the Genetics Core, Wellcome Trust Clinical Research Facility, University of Edinburgh for help with microarray analysis and to Dr Michael Boylan, Flow Cytometry Core Facility, University Dundee for FACS advice

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Medical history - Your doctor will ask about risk factors like digestive disorders, vegetarian/vegan diets, medications, and family history

After brain fixation, dehydration, incubation, and paraffin embedding, tissue was sectioned and stained with Congo red dye