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These therapies are generally well tolerated when monitored, but possible effects include water retention or swelling, joint or nerve discomfort, irritation at the injection site, and shifts in blood sugar if growth hormone runs too high

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Weight loss is itself a confound, and a serious one for stimulant users who are often already lean

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and Oura Ring) has been shown to be consistent with clinical actigraphy measurements, but also overestimates sleep and underestimates wakefulness in bed compared with polysomnography