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Apart from its intrinsic function in tumor and immune cells, cGAS-STING can signal intercellularly by cGAMP spreading to neighboring cells via gap junctions (134, 216, 217)

Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

Human topical GHK-Cu research has looked at changes over much longer periods

Monepantel antitumor activity is mediated through inhibition of major cell cycle and tumor growth signaling pathways

Sources: PMID 18271889, 36986081, 38320260, 38365549, 39186190, 40005053 Saffron is having a moment its kind of amazing because its the most expensive spice in the world yet all of these benefits keep popping up around what it can do as a Supplement

And I cant really sugar coat this at all