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One of the included studies (Allen and Bradley) found no significant change in melanin index, highlighting inconsistency in outcomes

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However, superoxide and hydrogen peroxide play a physiological role in signaling molecules and regulate apoptosis, cell proliferation, and cell differentiation 18,19

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PGD 2 , PGE 2 and PGF 2 act as hormones that bind to G-protein coupled receptors which regulate other hormones and neurotransmittors

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