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It features a heterodifunctional molecule integrating two crucial ligands: one targeting and binding to the protein of interest, and another engaging with an E3 ligase, a pivotal element within the ubiquitin-proteasome system tasked with marking proteins for degradation (Zeng et al., 2021)
Epitalon was initially shown to induce telomerase activity and elongate telomeres in human somatic cells by Khavinson in 2003
Significant healing progress by weeks 3 to 4
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