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For continuous outcomes (mean percent change in bodyweight and mean change in HbA1c [%]), the relative treatment effect was evaluated using the mean difference
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Variable SHAP values for each individual in the five left-out groups were extracted from corresponding xgboost models trained on the remaining 80% participants for each variable group using SHAPforxgboost (0.1.0) and averaged over 100 iterations
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Patients with severe cardiovascular disease or other metabolic disorders, excluding diabetes